| Indianapolis Colts (11-5) | [-1] | at | Tennessee Titans (11-5) | SUN 1 | |
| Tampa Bay Buccaneers (11-5) | [-2] | at | Los Angeles Rams (10-6) | SUN 4 | |
| Chicago Bears (8-8) | [-0] | at | Cleveland Browns (11-5) | SUN 1 | |
| Washington Football Team (7-9) | at | Buffalo Bills (13-3) | [-4] | SUN 1 | |
| Los Angeles Chargers (7-9) | at | Kansas City Chiefs (14-2) | [-5] | SUN 1 | |
| Seattle Seahawks (12-4) | [-4] | at | Minnesota Vikings (7-9) | SUN 4 | |
| Miami Dolphins (10-6) | [-3] | at | Las Vegas Raiders (8-8) | SUN 4 | |
| Green Bay Packers (13-3) | [-5] | at | San Francisco 49ers (6-10) | SUN 8 | |
| New Orleans Saints (12-4) | [-5] | at | New England Patriots (7-9) | SUN 1 | |
| Philadelphia Eagles (4-11-1) | at | Dallas Cowboys (6-10) | [-0] | MON 8 | |
| Cincinnati Bengals (4-11-1) | at | Pittsburgh Steelers (12-4) | [-7] | SUN 1 | |
| Atlanta Falcons (4-12) | [-2] | at | New York Giants (6-10) | SUN 1 | |
| Carolina Panthers (5-11) | [-1] | at | Houston Texans (4-12) | THU 8 | |
| Baltimore Ravens (11-5) | [-10] | at | Detroit Lions (5-11) | SUN 1 | |
| New York Jets (2-14) | at | Denver Broncos (5-11) | [-3] | SUN 4 | |
| Arizona Cardinals (8-8) | [-7] | at | Jacksonville Jaguars (1-15) | SUN 1 |
Predictions for first three weeks are based on last year's records
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