| Houston Texans (11-5) | at | New Orleans Saints (13-3) | [-2] | MON 7 | |
| Indianapolis Colts (10-6) | at | Los Angeles Chargers (12-4) | [-0] | SUN 4 | |
| Pittsburgh Steelers (9-6-1) | at | New England Patriots (11-5) | [-1] | SUN 8 | |
| Los Angeles Rams (13-3) | [-5] | at | Carolina Panthers (7-9) | SUN 1 | |
| Tennessee Titans (9-7) | [-1] | at | Cleveland Browns (7-8-1) | SUN 1 | |
| Atlanta Falcons (7-9) | at | Minnesota Vikings (8-7-1) | [-1] | SUN 1 | |
| Green Bay Packers (6-9-1) | at | Chicago Bears (12-4) | [-5] | THU 8 | |
| New York Giants (5-11) | at | Dallas Cowboys (10-6) | [-2] | SUN 4 | |
| Washington Redskins (7-9) | at | Philadelphia Eagles (9-7) | [-3] | SUN 1 | |
| Cincinnati Bengals (6-10) | at | Seattle Seahawks (10-6) | [-5] | SUN 4 | |
| Kansas City Chiefs (12-4) | [-7] | at | Jacksonville Jaguars (5-11) | SUN 1 | |
| Baltimore Ravens (10-6) | [-7] | at | Miami Dolphins (7-9) | SUN 1 | |
| Buffalo Bills (6-10) | [-0] | at | New York Jets (4-12) | SUN 1 | |
| San Francisco 49ers (4-12) | at | Tampa Bay Buccaneers (5-11) | [-1] | SUN 4 | |
| Denver Broncos (6-10) | [-5] | at | Oakland Raiders (4-12) | MON 10 | |
| Detroit Lions (6-10) | [-5] | at | Arizona Cardinals (3-13) | SUN 4 |
First three weeks of games use last year's team records.
