| Kansas City Chiefs (14-2) | at | Baltimore Ravens (11-5) | [-2] | SUN 8 | |
| Tennessee Titans (11-5) | at | Seattle Seahawks (12-4) | [-1] | SUN 4 | |
| Buffalo Bills (13-3) | [-2] | at | Miami Dolphins (10-6) | SUN 1 | |
| Los Angeles Rams (10-6) | at | Indianapolis Colts (11-5) | [-0] | SUN 1 | |
| Las Vegas Raiders (8-8) | at | Pittsburgh Steelers (12-4) | [-5] | SUN 1 | |
| Houston Texans (4-12) | at | Cleveland Browns (11-5) | [-2] | SUN 1 | |
| Minnesota Vikings (7-9) | at | Arizona Cardinals (8-8) | [-3] | SUN 4 | |
| Dallas Cowboys (6-10) | at | Los Angeles Chargers (7-9) | [-1] | SUN 4 | |
| New Orleans Saints (12-4) | [-6] | at | Carolina Panthers (5-11) | SUN 1 | |
| New York Giants (6-10) | at | Washington Football Team (7-9) | [-3] | THU 8 | |
| Atlanta Falcons (4-12) | at | Tampa Bay Buccaneers (11-5) | [-5] | SUN 4 | |
| Detroit Lions (5-11) | at | Green Bay Packers (13-3) | [-9] | MON 8 | |
| Cincinnati Bengals (4-11-1) | at | Chicago Bears (8-8) | [-4] | SUN 1 | |
| San Francisco 49ers (6-10) | [-2] | at | Philadelphia Eagles (4-11-1) | SUN 1 | |
| Denver Broncos (5-11) | [-2] | at | Jacksonville Jaguars (1-15) | SUN 1 | |
| New England Patriots (7-9) | [-6] | at | New York Jets (2-14) | SUN 1 |
Predictions for first three weeks are based on last year's records
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