| Houston Texans (11-5) | at | Los Angeles Chargers (12-4) | [-0] | SUN 4 | |
| New Orleans Saints (13-3) | [-2] | at | Seattle Seahawks (10-6) | SUN 4 | |
| Baltimore Ravens (10-6) | at | Kansas City Chiefs (12-4) | [-1] | SUN 1 | |
| Los Angeles Rams (13-3) | [-6] | at | Cleveland Browns (7-8-1) | SUN 8 | |
| Atlanta Falcons (7-9) | at | Indianapolis Colts (10-6) | [-3] | SUN 1 | |
| Detroit Lions (6-10) | at | Philadelphia Eagles (9-7) | [-2] | SUN 1 | |
| Miami Dolphins (7-9) | at | Dallas Cowboys (10-6) | [-4] | SUN 1 | |
| Denver Broncos (6-10) | [-0] | at | Green Bay Packers (6-9-1) | SUN 1 | |
| Chicago Bears (12-4) | [-7] | at | Washington Redskins (7-9) | MON 8 | |
| Tennessee Titans (9-7) | [-2] | at | Jacksonville Jaguars (5-11) | THU 8 | |
| Cincinnati Bengals (6-10) | [-1] | at | Buffalo Bills (6-10) | SUN 1 | |
| New York Giants (5-11) | [-1] | at | Tampa Bay Buccaneers (5-11) | SUN 4 | |
| Pittsburgh Steelers (9-6-1) | [-5] | at | San Francisco 49ers (4-12) | SUN 4 | |
| New York Jets (4-12) | at | New England Patriots (11-5) | [-7] | SUN 1 | |
| Oakland Raiders (4-12) | at | Minnesota Vikings (8-7-1) | [-6] | SUN 1 | |
| Carolina Panthers (7-9) | [-6] | at | Arizona Cardinals (3-13) | SUN 4 |
Last year's records used for first three weeks
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