| Los Angeles Chargers (10-7) | [-0] | at | Minnesota Vikings (13-4) | SUN 1 | |
| New York Giants (9-7-1) | at | San Francisco 49ers (13-4) | [-5] | THU 8 | |
| Philadelphia Eagles (14-3) | [-5] | at | Tampa Bay Buccaneers (8-9) | MON 7 | |
| Buffalo Bills (13-3) | [-6] | at | Washington Commanders (8-8-1) | SUN 1 | |
| Carolina Panthers (7-10) | at | Seattle Seahawks (9-8) | [-1] | SUN 4 | |
| New Orleans Saints (7-10) | at | Green Bay Packers (8-9) | [-0] | SUN 1 | |
| Atlanta Falcons (7-10) | at | Detroit Lions (9-8) | [-1] | SUN 1 | |
| Pittsburgh Steelers (9-8) | at | Las Vegas Raiders (6-11) | [-0] | SUN 8 | |
| New England Patriots (8-9) | [-1] | at | New York Jets (7-10) | SUN 1 | |
| Tennessee Titans (7-10) | at | Cleveland Browns (7-10) | [-1] | SUN 1 | |
| Los Angeles Rams (5-12) | at | Cincinnati Bengals (12-4) | [-5] | MON 8 | |
| Denver Broncos (5-12) | at | Miami Dolphins (9-8) | [-2] | SUN 1 | |
| Indianapolis Colts (4-12-1) | at | Baltimore Ravens (10-7) | [-5] | SUN 4 | |
| Chicago Bears (3-14) | at | Kansas City Chiefs (14-3) | [-8] | SUN 4 | |
| Dallas Cowboys (12-5) | [-7] | at | Arizona Cardinals (4-13) | SUN 4 | |
| Houston Texans (3-13-1) | at | Jacksonville Jaguars (9-8) | [-5] | SUN 1 |
Predictions for first three weeks are based on last year's records
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