| New Orleans Saints (11-5) | [-3] | at | Atlanta Falcons (10-6) | SUN 1 | |
| New England Patriots (13-3) | [-4] | at | Detroit Lions (9-7) | SUN 8 | |
| Los Angeles Chargers (9-7) | at | Los Angeles Rams (11-5) | [-2] | SUN 4 | |
| Dallas Cowboys (9-7) | at | Seattle Seahawks (9-7) | [-0] | SUN 4 | |
| Buffalo Bills (9-7) | at | Minnesota Vikings (13-3) | [-6] | SUN 1 | |
| Cincinnati Bengals (7-9) | at | Carolina Panthers (11-5) | [-3] | SUN 1 | |
| Tennessee Titans (9-7) | at | Jacksonville Jaguars (10-6) | [-5] | SUN 1 | |
| Pittsburgh Steelers (13-3) | [-5] | at | Tampa Bay Buccaneers (5-11) | MON 8 | |
| Green Bay Packers (7-9) | at | Washington Redskins (7-9) | [-1] | SUN 1 | |
| Chicago Bears (5-11) | [-0] | at | Arizona Cardinals (8-8) | SUN 4 | |
| San Francisco 49ers (6-10) | at | Kansas City Chiefs (10-6) | [-4] | SUN 1 | |
| Oakland Raiders (6-10) | [-1] | at | Miami Dolphins (6-10) | SUN 1 | |
| Denver Broncos (5-11) | at | Baltimore Ravens (9-7) | [-6] | SUN 1 | |
| Indianapolis Colts (4-12) | at | Philadelphia Eagles (13-3) | [-9] | SUN 1 | |
| New York Giants (3-13) | at | Houston Texans (4-12) | [-1] | SUN 1 | |
| New York Jets (5-11) | [-3] | at | Cleveland Browns (0-16) | THU 8 |
Last season's results are used for the first three weeks.
