| Kansas City Chiefs (12-4) | at | New England Patriots (14-2) | [-4] | THU 8 | |
| New York Giants (11-5) | at | Dallas Cowboys (13-3) | [-3] | SUN 8 | |
| Oakland Raiders (12-4) | [-1] | at | Tennessee Titans (9-7) | SUN 1 | |
| Seattle Seahawks (10-5-1) | [-1] | at | Green Bay Packers (10-6) | SUN 4 | |
| Tampa Bay Buccaneers (9-7) | [-0] | at | Miami Dolphins (10-6) | SUN 1 | |
| New Orleans Saints (7-9) | at | Minnesota Vikings (8-8) | [-0] | MON 7 | |
| Philadelphia Eagles (7-9) | [-1] | at | Washington Redskins (8-7-1) | SUN 1 | |
| Arizona Cardinals (7-8-1) | [-2] | at | Detroit Lions (9-7) | SUN 1 | |
| Baltimore Ravens (8-8) | [-0] | at | Cincinnati Bengals (6-9-1) | SUN 1 | |
| Los Angeles Chargers (5-11) | at | Denver Broncos (9-7) | [-2] | MON 10 | |
| Jacksonville Jaguars (3-13) | at | Houston Texans (9-7) | [-1] | SUN 1 | |
| New York Jets (5-11) | at | Buffalo Bills (7-9) | [-5] | SUN 1 | |
| Indianapolis Colts (8-8) | [-6] | at | Los Angeles Rams (4-12) | SUN 4 | |
| Atlanta Falcons (11-5) | [-8] | at | Chicago Bears (3-13) | SUN 1 | |
| Pittsburgh Steelers (11-5) | [-8] | at | Cleveland Browns (1-15) | SUN 1 | |
| Carolina Panthers (6-10) | [-4] | at | San Francisco 49ers (2-14) | SUN 4 |
Records from last year are used for the first three weeks.
