| Green Bay Packers (13-3) | at | Minnesota Vikings (10-6) | [-1] | SUN 1 | |
| Houston Texans (10-6) | at | Kansas City Chiefs (12-4) | [-5] | THU 8 | |
| Seattle Seahawks (11-5) | [-1] | at | Atlanta Falcons (7-9) | SUN 1 | |
| Tampa Bay Buccaneers (7-9) | at | New Orleans Saints (13-3) | [-3] | SUN 4 | |
| Dallas Cowboys (8-8) | [-3] | at | Los Angeles Rams (9-7) | SUN 8 | |
| Tennessee Titans (9-7) | [-3] | at | Denver Broncos (7-9) | MON 1 | |
| New York Jets (7-9) | at | Buffalo Bills (10-6) | [-4] | SUN 1 | |
| Las Vegas Raiders (7-9) | [-1] | at | Carolina Panthers (5-11) | SUN 1 | |
| Arizona Cardinals (5-10-1) | at | San Francisco 49ers (13-3) | [-8] | SUN 4 | |
| Cleveland Browns (6-10) | at | Baltimore Ravens (14-2) | [-10] | SUN 1 | |
| Indianapolis Colts (7-9) | [-3] | at | Jacksonville Jaguars (6-10) | SUN 1 | |
| Chicago Bears (8-8) | [-2] | at | Detroit Lions (3-12-1) | SUN 1 | |
| Pittsburgh Steelers (8-8) | [-3] | at | New York Giants (4-12) | MON 7 | |
| Philadelphia Eagles (9-7) | [-6] | at | Washington Football Team (3-13) | SUN 1 | |
| Miami Dolphins (5-11) | at | New England Patriots (12-4) | [-12] | SUN 1 | |
| Los Angeles Chargers (5-11) | [-4] | at | Cincinnati Bengals (2-14) | SUN 4 |
Predictions for first three weeks are based on last year's records
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