| Name (* = Rookie) | Team | G | Comp | Att | PassYds | PassTD | Int | RushYds | RushTD | MVP Score | Adj Score |
| Tom Brady | TB | 3 | 97 | 141 | 1087 | 10 | 2 | 20 | 1 | 350 | 378 |
| Kyler Murray | ARI | 3 | 78 | 102 | 1005 | 7 | 4 | 70 | 3 | 299 | 366 |
| Derek Carr | LV | 3 | 88 | 136 | 1203 | 6 | 2 | 13 | 0 | 289 | 354 |
| Matthew Stafford | LAR | 3 | 66 | 94 | 942 | 9 | 1 | -6 | 0 | 277 | 339 |
| Sam Darnold | CAR | 3 | 73 | 107 | 888 | 3 | 1 | 17 | 3 | 252 | 309 |
| Teddy Bridgewater | DEN | 3 | 73 | 95 | 827 | 4 | 0 | 44 | 0 | 251 | 307 |
| Dak Prescott | DAL | 3 | 86 | 111 | 878 | 6 | 2 | 19 | 0 | 276 | 298 |
| Kirk Cousins | MIN | 3 | 88 | 119 | 918 | 8 | 0 | 37 | 0 | 320 | 292 |
| Josh Allen | BUF | 3 | 79 | 127 | 807 | 7 | 1 | 88 | 1 | 269 | 291 |
| Justin Herbert | LAC | 3 | 88 | 126 | 956 | 6 | 3 | 27 | 0 | 266 | 287 |
| Patrick Mahomes | KC | 3 | 78 | 111 | 940 | 9 | 3 | 66 | 1 | 293 | 267 |
| Russell Wilson | SEA | 3 | 63 | 86 | 895 | 7 | 0 | 32 | 0 | 265 | 242 |
| Jimmy Garoppolo | SF | 3 | 64 | 95 | 760 | 4 | 1 | 26 | 1 | 215 | 232 |
| Ryan Tannehill | TEN | 3 | 66 | 102 | 756 | 4 | 3 | 100 | 1 | 201 | 217 |
| Aaron Rodgers | GB | 3 | 60 | 88 | 649 | 6 | 2 | 6 | 0 | 197 | 213 |
| Jalen Hurts | PHI | 3 | 64 | 97 | 780 | 5 | 2 | 179 | 1 | 230 | 210 |
| Lamar Jackson | BAL | 3 | 53 | 87 | 761 | 3 | 3 | 251 | 2 | 193 | 208 |
| Baker Mayfield | CLE | 3 | 59 | 80 | 780 | 2 | 2 | 48 | 1 | 189 | 204 |
| Matt Ryan | ATL | 3 | 83 | 117 | 707 | 4 | 3 | 10 | 0 | 213 | 194 |
| Joe Burrow | CIN | 3 | 53 | 75 | 640 | 7 | 4 | 9 | 0 | 178 | 192 |
| Ben Roethlisberger | PIT | 3 | 83 | 130 | 801 | 3 | 3 | 10 | 0 | 200 | 183 |
| Jared Goff | DET | 3 | 86 | 123 | 801 | 5 | 2 | 64 | 0 | 251 | 177 |
| Taylor Heinicke | WAS | 3 | 59 | 85 | 670 | 5 | 3 | 44 | 1 | 193 | 176 |
| Mac Jones * | NE | 3 | 81 | 120 | 737 | 2 | 3 | 28 | 0 | 189 | 172 |
| Jameis Winston | NO | 3 | 38 | 63 | 387 | 7 | 2 | 60 | 1 | 155 | 167 |
| Daniel Jones | NYG | 3 | 68 | 104 | 782 | 2 | 0 | 161 | 2 | 234 | 165 |
| Carson Wentz | IND | 3 | 64 | 106 | 692 | 3 | 1 | 60 | 0 | 181 | 128 |
| Tyrod Taylor | HOU | 2 | 31 | 44 | 416 | 3 | 0 | 55 | 1 | 136 | 124 |
| Jacoby Brissett | MIA | 3 | 56 | 89 | 384 | 0 | 1 | 49 | 1 | 122 | 111 |
| Trevor Lawrence * | JAX | 3 | 64 | 118 | 669 | 5 | 7 | 46 | 0 | 125 | 88 |
| Andy Dalton | CHI | 2 | 36 | 49 | 262 | 1 | 1 | 38 | 0 | 89 | 81 |
| Davis Mills * | HOU | 2 | 27 | 46 | 270 | 2 | 1 | -1 | 0 | 71 | 65 |
| Zach Wilson * | NYJ | 3 | 58 | 105 | 628 | 2 | 7 | 21 | 0 | 83 | 59 |
| Tua Tagovailoa | MIA | 2 | 17 | 31 | 215 | 1 | 1 | 1 | 1 | 51 | 47 |
| Trey Lance * | SF | 2 | 1 | 1 | 5 | 1 | 0 | 3 | 1 | 22 | 24 |
| Justin Fields * | CHI | 3 | 14 | 35 | 138 | 0 | 1 | 46 | 1 | 25 | 23 |
| Taysom Hill | NO | 3 | 1 | 1 | 3 | 0 | 0 | 49 | 1 | 17 | 18 |
| Jordan Love * | GB | 2 | 5 | 7 | 68 | 0 | 0 | -3 | 0 | 14 | 15 |
| Name (* = Rookie) | Team | G | Rush | RushYds | RushTD | Rec | RecYds | RecTD | MVP Score | Adj Score |
| Derrick Henry | TEN | 3 | 80 | 353 | 3 | 12 | 105 | 0 | 240 | 259 |
| Aaron Jones | GB | 3 | 41 | 158 | 2 | 10 | 75 | 3 | 192 | 207 |
| Christian McCaffrey | CAR | 3 | 52 | 201 | 1 | 16 | 163 | 0 | 164 | 201 |
| Nick Chubb | CLE | 3 | 48 | 262 | 3 | 3 | 21 | 0 | 172 | 186 |
| Melvin Gordon | DEN | 3 | 42 | 193 | 2 | 6 | 76 | 0 | 144 | 176 |
| Ezekiel Elliott | DAL | 3 | 44 | 199 | 3 | 7 | 53 | 0 | 160 | 173 |
| Austin Ekeler | LAC | 3 | 35 | 166 | 1 | 15 | 113 | 1 | 148 | 160 |
| Joe Mixon | CIN | 3 | 67 | 286 | 1 | 6 | 29 | 0 | 144 | 156 |
| Kareem Hunt | CLE | 3 | 29 | 165 | 2 | 10 | 104 | 0 | 144 | 156 |
| Alvin Kamara | NO | 3 | 52 | 177 | 0 | 10 | 62 | 2 | 132 | 143 |
| Chris Carson | SEA | 3 | 41 | 202 | 3 | 5 | 28 | 0 | 152 | 139 |
| Darrell Henderson | LAR | 2 | 29 | 123 | 2 | 4 | 46 | 0 | 104 | 127 |
| Tony Pollard | DAL | 3 | 27 | 183 | 1 | 8 | 65 | 0 | 116 | 125 |
| Chase Edmonds | ARI | 3 | 31 | 135 | 0 | 16 | 121 | 0 | 100 | 122 |
| Antonio Gibson | WAS | 3 | 45 | 190 | 0 | 6 | 95 | 1 | 132 | 120 |
| Najee Harris * | PIT | 3 | 40 | 123 | 0 | 20 | 149 | 1 | 128 | 117 |
| Zack Moss | BUF | 2 | 21 | 86 | 2 | 5 | 39 | 1 | 108 | 117 |
| James Conner | ARI | 3 | 35 | 122 | 2 | 1 | 10 | 0 | 92 | 113 |
| Dalvin Cook | MIN | 2 | 42 | 192 | 1 | 8 | 60 | 0 | 120 | 110 |
| David Montgomery | CHI | 3 | 46 | 203 | 1 | 6 | 49 | 0 | 120 | 110 |
| Peyton Barber | LV | 2 | 36 | 143 | 1 | 3 | 31 | 0 | 88 | 108 |
| Ty'Son Williams * | BAL | 3 | 27 | 164 | 1 | 5 | 45 | 0 | 100 | 108 |
| Javonte Williams * | DEN | 3 | 39 | 138 | 1 | 5 | 39 | 0 | 88 | 108 |
| D'Andre Swift | DET | 3 | 33 | 123 | 1 | 19 | 166 | 1 | 152 | 107 |
| Devin Singletary | BUF | 3 | 35 | 180 | 1 | 6 | 17 | 0 | 96 | 104 |
| Clyde Edwards-Helaire | KC | 3 | 44 | 189 | 0 | 5 | 38 | 1 | 108 | 99 |
| Kenyan Drake | LV | 3 | 21 | 44 | 0 | 13 | 138 | 0 | 72 | 88 |
| Jamaal Williams | DET | 3 | 28 | 121 | 2 | 13 | 93 | 0 | 124 | 88 |
| Damien Harris | NE | 3 | 45 | 176 | 1 | 5 | 16 | 0 | 96 | 88 |
| Elijah Mitchell * | SF | 2 | 36 | 146 | 1 | 2 | 11 | 0 | 80 | 86 |
| James Robinson | JAX | 3 | 31 | 160 | 1 | 12 | 92 | 0 | 120 | 85 |
| Latavius Murray | BAL | 3 | 26 | 92 | 2 | 0 | 0 | 0 | 76 | 82 |
| Miles Sanders | PHI | 3 | 30 | 156 | 0 | 8 | 71 | 0 | 88 | 80 |